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Inside a recent study, we described the identification along with the characterization of a different atypical opioid receptor with unique detrimental regulatory Homes in the direction of opioid peptides.1 Our final results confirmed that ACKR3/CXCR7, hitherto known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can be a wide-s